Neuroprotective mechanism involved in spinal cord stimulation postconditioning

摘要

Objectives: Delayed paraplegia developed postoperatively after thoracoabdominal aneurysm surgery is primarily associated with spinal cord ischemia/reperfusion injury. Our previous study suggested that spinal cord stimulation postconditioning protected the spinal cord from ischemia/reperfusion injury through microglia inhibition. In this study, we further investigated whether alpha 7 nicotinic acetylcholine receptors were involved in the neuroprotective mechanism of spinal cord stimulation.