Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface

Moghaddas Fiona; Zeng Ping; Zhang Yuxia; Schuetzle Heike; Brenner Sebastian; Hofmann Sigrun R.; Berner Reinhard; Zhao Yuanbo; Lu Bingtai; Chen Xiaoyun; Zhang Li; Cheng Suyun; Winkler Stefan; Lehmberg Kai; Canna Scott W.; Czabotar Peter E.; Wicks Ian P.; De Nardo Dominic; Hedrich Christian M.; Zeng Huasong; Masters Seth L.

首页> 外文期刊>The Journal of Allergy and Clinical Immunology >Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface

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Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface

机译：NLRC4中的自身炎性突变显示出富含亮氨酸的重复（LRR）-LRR低聚界面

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Background: Monogenic autoinflammatory disorders are characterized by dysregulation of the innate immune system, for example by gain-of-function mutations in inflammasome-forming proteins, such as NOD-like receptor family CARD-containing 4 protein (NLRC4).

机译：背景：单一的自身炎性疾病的特征在于先天免疫系统的失调，例如通过炎症组蛋白质中的功能突变，例如Nod样受体家族卡的4蛋白（NLRC4）。

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来源
《The Journal of Allergy and Clinical Immunology》 |2018年第6期|共18页
作者
Moghaddas Fiona; Zeng Ping; Zhang Yuxia; Schuetzle Heike; Brenner Sebastian; Hofmann Sigrun R.; Berner Reinhard; Zhao Yuanbo; Lu Bingtai; Chen Xiaoyun; Zhang Li; Cheng Suyun; Winkler Stefan; Lehmberg Kai; Canna Scott W.; Czabotar Peter E.; Wicks Ian P.; De Nardo Dominic; Hedrich Christian M.; Zeng Huasong; Masters Seth L.;
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作者单位

Walter &

Eliza Hall Inst Med Res Inflammat Div Parkville Vic Australia;

Guangzhou Women &

Childrens Med Ctr Dept Rheumatol Guangzhou Guangdong Peoples R China;

Guangzhou Inst Paediat Immunol Lab Guangzhou Guangdong Peoples R China;

Tech Univ Dresden Univ Hosp Dept Pediat Dresden Germany;

Tech Univ Dresden Univ Hosp Dept Pediat Dresden Germany;

Tech Univ Dresden Univ Hosp Dept Pediat Dresden Germany;

Tech Univ Dresden Univ Hosp Dept Pediat Dresden Germany;

Guangzhou Inst Paediat Immunol Lab Guangzhou Guangdong Peoples R China;

Guangzhou Inst Paediat Immunol Lab Guangzhou Guangdong Peoples R China;

Guangzhou Inst Paediat Immunol Lab Guangzhou Guangdong Peoples R China;

Guangzhou Inst Paediat Immunol Lab Guangzhou Guangdong Peoples R China;

Guangzhou Women &

Childrens Med Ctr Dept Rheumatol Guangzhou Guangdong Peoples R China;

Tech Univ Dresden Univ Hosp Dept Pediat Dresden Germany;

Univ Med Ctr Hamburg Eppendorf Div Pediat Stem Cell Transplantat &

Immunol Hamburg Germany;

UPMC Childrens Hosp Pittsburgh RK Mellon Inst Pediat Rheumatol Pittsburgh PA USA;

Walter &

Eliza Hall Inst Med Res Struct Biol Div Parkville Vic Australia;

Walter &

Eliza Hall Inst Med Res Inflammat Div Parkville Vic Australia;

Walter &

Eliza Hall Inst Med Res Inflammat Div Parkville Vic Australia;

Tech Univ Dresden Univ Hosp Dept Pediat Dresden Germany;

Guangzhou Women &

Childrens Med Ctr Dept Rheumatol Guangzhou Guangdong Peoples R China;

Walter &

Eliza Hall Inst Med Res Inflammat Div Parkville Vic Australia;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Autoinflammatory disease; periodic fever syndrome; NLRC4; macrophage activation syndrome; inflammasome; Nod-like receptor; IPAF; IL-18;

机译：自身炎症性疾病;定期发烧综合征;NLRC4;巨噬细胞激活综合征;炎症;点燃般的受体;IPAF;IL-18;

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专利

1. Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface [J] . Moghaddas Fiona, Zeng Ping, Zhang Yuxia, The Journal of Allergy and Clinical Immunology . 2018,第6期

机译：NLRC4中的自身炎性突变显示出富含亮氨酸的重复（LRR）-LRR低聚界面
2. A novel de novo NLRC4 mutation reinforces the likely pathogenicity of specific LRR domain mutation [J] . Chear Chai Teng, Nallusamy Revathy, Canna Scott W., Clinical immunology: The official journal of the Clinical Immunology Society . 2020,第1期

机译：一种新型Novo NLRC4突变强化了特定LRR结构域突变的可能致病性
3. Expression analysis of genes encoding malectin-like domain (MLD)- and leucine-rich repeat (LRR)- containing proteins in Arabidopsis thaliana [J] . Sultana Mst Momtaz, Hachiya Takushi, Dutta Amit Kumar, Bioscience, Biotechnology, and Biochemistry . 2020,第1期

机译：编码α样域（MLD） - 和富含亮氨酸富含重复（LRR）的基因的表达分析 - 拟南芥蛋白质
4. Phage-Library Displaying Toll-Like Receptor as Leucine-Rich Repeat (LRR) Protein Scaffold [C] . Takuya Kamino, Koichi Tanaka, Satoshi Muraoka Japanese peptide symposium . 2010

机译：噬菌体文库显示富含亮氨酸的重复（LRR）蛋白质支架
5. Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)–LRR oligomerization interface [O] . Fiona Moghaddas, Ping Zeng, Yuxia Zhang, -1

机译：NLRC4中的自体炎症突变揭示了富含亮氨酸的重复（LRR）-LRR寡聚界面
6. Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)–LRR oligomerization interface [O] . Fiona Moghaddas, Ping Zeng, Yuxia Zhang, 2018

机译：NLRC4中的自身炎性突变显示出富含亮氨酸的重复（LRR）-LRR低聚界面

Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface

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