Quantitative analysis of fragrance in selectable one dimensional ortwo dimensional gas chromatography-mass spectrometry withsimultaneous detection of multiple detectors in single injection

摘要

A selectable one-dimensional (1D) or two-dimensional (2D) gas chromatography-mass spectrometry(GC-MS) system coupled with flame ionization detector (FID) and olfactory detection port (ODP) wasemployed in this study to analyze perfume oil and fragrance in shower gel. A split/splitless (SSL) injectorand a programmable temperature vaporization (PTV) injector are connected via a 2-way splitter of cap-illary flow technology (CFT) in this selectable1D/2D GC-MS/FID/ODP system to facilitate liquid sampleinjections and thermal desorption (TD) for stir bar sorptive extraction (SBSE) technique, respectively.The dual-linked injectors set-up enable the use of two different injector ports (one at a time) in singlesequence run without having to relocate the ~1D capillary column from one inlet to another. Target ana-lytes were separated in ~1D GC-MS/FID/ODP and followed by further separation of co-elution mixturefrom ~1D in ~2D GC-MS/FID/ODP in single injection without any instrumental reconfiguration. A1D/2Dquantitative analysis method was developed and validated for its repeatability - t_R; calculated linearretention indices (LRI); response ratio in both MS and FID signal, limit of detection (LOD), limit of quan-titation (LOQ), as well as linearity over a concentration range. The method was successfully applied inquantitative analysis of perfume solution at different concentration level (RSD ≤ 0.01%, n = 5) and showergel spiked with perfume at different dosages (RSD ≤ 0.04%, n = 5) with good recovery (96-103% for SSLinjection; 94-107% for stir bar sorptive extraction-thermal desorption (SBSE-TD).