Drinking alcohol during antidepressant treatment- a cause for concern?

摘要

PRECLINICAL studies of interactions between selective serotonin reuptake inhibitors (SSRIs) and alcohol have mainly been acute experiments in healthy volunteers, using various psychological performance tests. The combination generally fails to impair function or produce other effects beyond those of alcohol alone. Alcohol use is common in depression, but its interaction with antidepressants in patients has been little studied except in problem drinkers. In a subgroup of these,.alcohol problems seem to become worse.