A convenient method for preparing aromatic ketones from acyl chlorides and arylboronic acids via Suzuki-Miyaura type coupling reaction

摘要

Aromatic ketones are synthesized efficiently via palladium-catalyzed cross-coupling reaction of boronic acids with acyl chlorides in the presence of K_3PO_4 hydrate in toluene. This allows the use of aliphatic acyl chlorides as the starting material. Hydrated water plays a significant role as an H_2O source to activate the catalytic system.