Increasing the inhibitory potency of L-arabino-imidazolo-[1,2]-piperidinose towards β-D-glucosidase and β-D-galactosidase

摘要

The synthesis of some potent inhibitors of two retaining β-glycosidases was achieved by introducing aglycon-mimics into the imidazole moiety of L-arabino azasugar 1. The strongest inhibition was observed with the phenyl-ethyl substituent at C(2) of 1 against β-D-galactosidase and β-D-glucosidase, whereas the hydroxymethyl group at C(2) increased only slightly the inhibitory properties.