Relative Inhibitory Potencies of Chlorpyrifos Oxon, Chlorpyrifos Methyl Oxon, and Mipafox for Acetylcholinesterase Versus Neuropathy Target Esterase

摘要

The relative inhibitory potency (RIP) of an organophosphorus (OP) inhibitor against acetylcholinesterase(AChE) versus neuropathy target esterase (NTE) is ki(AChE)/ki(NTE), where ki is the bimolecular rate constant of inhibition. RIPs>1 correlate with the inability of ageable OP inhibitors or their parent compounds to produce OP induced delayed neurotoxicity (OPIDN) at doses.