Studies on Structure-Activity Relationship of N-Substituted Phenyl Cinnamide Compounds with Antitumor Activity

摘要

The relationship of structure and antitumor activity of N-substituted phenyl cinnamide derivatives were studied. The main influntcing factor is LUMO orbital of molecular. When these compounds reacted with the receptors, they could accept the electrons. The C(8) atom on carbonyl is the active site. The result of QSAR showed that there is a positive correlation between the antitumor activity and the E_(lumo) of compounds.