Supramolecular Bioinorganic Chemistry:Model Complexes of Cytochrome c Oxidase Meet Functional Surfaces

摘要

A long-standing and still very vital branch of bioinorganic chemistry is the design and investigation of model substances mimicking functional and/or structural properties of enzyme active sites.This approach appears particularly successful for active sites containing a molecular cofactor such as a heme group or other bioporphyrinoids.Indeed,four of the binding positions of the metal ion in question are blocked already by the macrocycle in a kinetically inert fashion,so that the chemical reactivity is directed exclusively towards the desired distal or proximal position.Furthermore,porphyrins allow simple functional engineering of the second coordination sphere by covalently attaching selected substituents and groups to the ligand backbone.