Role of glucose metabolism in the recovery of postischemic LV mechanical function: effects of insulin and other metabolic modulators

摘要

myocardial ischemia is a common cause of morbidity and mortality, and there continues to be a great opportunity for the development of new cardioprotective interventions to reduce ischemic injury and enhance recovery of left ventricular (LV) mechanical function during postischemic reperfusion. Inasmuch as ischemia is associated with marked metabolic alterations, acute drug-induced modification of myocardial metabolism may provide useful therapeutic approaches to lessen ischemia and reperfusion injury (28, 41).