The development of clearance methods for measurement of glomerular filtration and tubular reabsorption.

摘要

This essay looks at the historical significance of four APS classic papers that are freely available online: Jolliffe N, Shannon JA, and Smith HW. The excretion of urine in the dog. III. The use of non-metabolized sugars in the measurement of the glomerular filtrate. Am J Physiol 100: 301-312, 1932 (http://ajplegacy.physiology.org/cgi/reprint/100/2/301). Shannon JA. The excretion of inulin by the dog. Am J Physiol 112: 405-413, 1935 (http://ajplegacy.physiology.org/cgi/reprint/112/3/405). Shannon JA and Fisher S. The renal tubular reabsorption of glucose in the normal dog. Am J Physiol 122: 765-774, 1938 (http://ajplegacy.physiology.org/cgi/reprint/122/3/765). Shannon JA, Farber S, and Troast L. The measurement of glucose Tm in the normal dog. Am J Physiol 133: 752-761, 1941 (http://ajplegacy.physiology.org/cgi/reprint/133/3/752).