The influence of acute exteral #gamma#-irradiation and disturbance of thyroid gland function on rat reproductive system and frequency of structural mutations in somatic cells of pregnant females and their offspring

摘要

Experimental hypofunction of thyroid gland, caused by mercazolil administration, and acute external exposure to 0.5 and 1.0 Gy of #gamma#-irradiation were shown to result in disturbance of reproductive function in puberal females and of estrogenreceptor interaction, in reduction of pregnancy probability, increase in pre- and postimplantation lethality of fetuses as well as in rise in the frequency of structural mutations in somatic cells of pregnant rats and their offspring.