Evaluation of the newly developed immunochromatography test kit for rapid detection and differentiation of norovirus GI and GII.

摘要

Viral gastroenteritis is one of the most common illnesses in humans worldwide [1]. Noroviruses (NoVs) are considered as the major cause of acute gastroenteritis in both children and adults in community-based gastroenteritis, and responsible for sporadic cases and several outbreaks in various epidemiological settings, including restaurants, schools, day-care centers, hospitals, nursing homes and cruise ships, resulting in over 267 000 000 annual infections worldwide. The common NoV found in humans was Gil and GI genogroups [2]. When outbreaks of diarrhea occur in communities, rapid virus identification is essential to ensure administration of the appropriate treatment and control. For this reason, a rapid and sensitive diagnostic tool, such as the immunochromatography (IC) test, is required. Recently, broad reactive monoclonal antibody against several NoV genogroups and genotypes had been produced in our laboratory [3] and several studies on the evaluation of IC test for NoV detections have been reported [4-7].