Stereoselective photodimerlzation and antimicrobial activities of heteroaryl chalcones and their photoproducts

摘要

Stereoselective photodimerization of heteroaryl chalcones 1-(furan-2-yl)-3-phenylprop-2-cn-1-one (1), 3-phcnyl-1-(thiophen-2-yl)prop-2-en-1-one (2) and 3-phenyl-1-(1H-pyrrol-2-yl)prop-2-en-1-one (3) has been studied. The heteroaryl chalcones and their photoproducts have also been tested for antimicrobial activity. The heteroaryl chalcones (1-3) showed good activity with minimum inhibitory concentration (MIC) in the range of 10-60 μg/mL. The comparison of percentage antimicrobial activities relative to that of standards revealed that the monomeric starting compounds were more active than the dimerization products.