Until World War II malaria have been the world's latest scourge, its steady accumulated toll for exceeding that of the more explosive plague. Even today probably over 200 million peoples are afflicted, and over a million die each year malaria. Knowledge of mosquito control, insecticides and antimalarials, however, have all but eradicated the disease in the more advanced countries, such as the "U.S.A"; similar have been made in certain relatively undeveloped countries, so that malaria now ranks second to tuberculosis in many of these countries. (1) The introduction of quinine in the nineteenth century has suppressde the disease somewhat, hewever great advances have bees achieved through the introduction of pamaquine in 1926 and quinacrine (atabrine) in 1930. These synthetics did not totally displace quinine. The continued search in this field has yielded other antimalerials, however because of the emergence of resistant strains of Plasmodia, the effectiveness of several of the newer agents is rapidly diminishing, so that not only are new drugs again being actively searched but combination of old drugs are on trial.
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