Cutaneous squamous cell carcinoma (SCC) is a common dermatologic condition. Most (>90%) cases are cured by local therapies.1 Therapy is poorly defined if not amenable to local treatment. We present a case of unresectable SCC responding to epidermal growth factor receptor (EGFR) inhibition. After SCC excision from his shoulder, a 47-year-old male developed multiple axillary nodal recurrences that were treated with surgery and chemoradiotherapy. The disease became unresectable because of axillary vessel and brachial plexus involvement. Severe pain 'was constant and only partly controlled with large analgesic doses.
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