Aminoglycoside residues in food of animal origin

摘要

The aminoglycoside antimicrobials are polar organic bases with bactericidal activity mostly against aerobic gram-negative bacteria. The group includes dihy-drostreptomycin, streptomycin, neomycin, kanamycin, gentamicin, and amikacin. Use of this groupof antimicrobials has declined because of resistance, particularly in the older drugs, and problems with toxicity but they still remain important in the treatment of serious gram-negative infections in animals. They are also a common source of violativeantimicrobial residues in food of animal origin. A number of veterinary organizations, including the Academy of Veterinary Consultants, the Society for Theriogenology the American Association of Bovine Practitioners, the AVMA, and several state veterinary medical associations, have established or support policies that discourage the extralabel use of aminoglycosides. The purpose of this digest is to give an overview of the pharmacokinetics and other properties of the aminoglycosides that contribute tothese residues so that practitioners can better understand the food-safety risks of using these antimicrobials in food-producing animals.