Genome-wide Proteomics, Chromosome-centric Human Proteome Project (C-HPP), Part II

摘要

With vibrant scientific meetings and collaborative efforts among the research teams responsible for mapping and characterizing the proteins of individual chromosomes, the Chromosome-Centric Human Proteome Project (C-HPP)1,2 consortium of the Human Proteome Project (HPP)~3 has entered its second productive year. In this Special Issue, we report substantial progress in networking, journal publications, information dissemination, and cooperative proteome analysis among chromosome teams. The annual Human Proteome Organization (HUPO) World Congress of Proteomics in Yokohama, Japan in September 2013 was a scientific showcase for the HPP, which is composed of two engines that include CHPP and B/D-HPP and the resource pillars. The result was an ideal working mode for translational proteome biology, which embraced basic molecular dynamics from genome to proteome and comprehensive approaches to disease mechanisms from cancers to preeclampsia and neural disease (Figure 1). The baseline metrics of proteomic mapping in a chromosome scaffold4 were updated~5 by reshaping the analysis of missing proteins and reinforcing the data sharing system through ProteomeXchange. We are grateful to all bioinformatics leaders such as Amos Bairoch and Lydie Lane at the Swiss Institute for Bioinformatics (neXtProt), Eric Deutsch at the Institute for Systems Biology (PeptideAtlas, SRM Atlas), Ron Beavis at the University of British Columbia (GPMDB), and Emma Lundberg at the Karolinska Institute (Human Protein Atlas) as well as the entire C-HPP bioinformatics unity group.