Antioxidising activity of cinnamic acid derivatives against oxidative stress induced by oxidising radicals

摘要

Cinnamic acid and its derivatives react with hydroxyl radical (HO~·), in neutral medium, to give hydroxylation products, whether on the benzene ring or on the exocyclic chain, and decarboxylation products. The latter compounds are also obtained after oxidation of the same substrates by the SO_4~(·-) radical anion. Evidence was provided for the protecting effects afforded by cinnamic acid and hydroxylated derivatives against oxidative reaction mediated by HO~·. By using adenine as a model compound, the results obtained suggest that the high protective effect is due to an antioxidising cascade process.