Although bisphosphonate therapy is effective in severe childhood osteoporosis, both short and long term side effects occur.1 We have treated a total of 124 children including those with severe Osteogenesis Imperfecta (OI) since 1998, and more recently, patients with other forms of osteoporosis (e.g. juvenile idiopathic osteoporosis or steroid induced) with serious fractures (e.g. vertebral crush fractures).
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