Antitumor Agents.239.Isolation,Structure Elucidation,Total Synthesis,and Anti-Breast Cancer Activity of Neo-tanshinlactone from Salvia miltiorrhiza

摘要

Neo-tanshinlactone(1)was isolated and synthesized for the first time and evaluated in vitro against several human cancer cell lines.Compound 1 showed significant inhibition against two ER+ human breast cancer cell lines and was 10-fold more potent and 20-fold more selective as compared to tamoxifen citrate.Compound 1 also potently inhibited an ER-,HER-2 overexpressing breast cancer cell line.Therefore,this novel compound merits further development as an anti-breast cancer drug candidate.