Antitumor Platinum Compounds: Synthesis, Structure and Biological Activity

摘要

;Contents: General introduction--(Survey of the development of platinum coordination compounds in the chemotherapy of cancer; and introduction to the work described in this thesis.); Synthesis and characterization of platinum and palladium compounds with nitrogen-donor ligands--(Introduction to the synthetic methods, methods used in the characterization of the compounds, coordination compounds of Pt(II) and Pd(II) with imidazole as a ligand, coordination compounds of Pt(II) with N-methylimidazole as a ligand, structural characterization of cis-dichlorobis(N-methyl-imidazole)platinum(II) and cis-dibromobis(N-methylimidazole) platinum(II), coordination compounds of Pt(II) and Pd(II) with pyrazole as a ligand, coordination compounds of Pt(II) with some other substituted azoles as ligands, coordination compounds of Pt(II) with histamine as a ligand, coordination compounds of Pt(II) and Pt(IV) with aliphatic diamines as ligands, and crystal and molecular structure of malonato(2,2-dimethyl-1,3-diaminopropane)platinum(II).); Biological tests of platinum compounds--(Introduction, test on prophage induction of lysogenic bacteria, antitumor activity of platinum compounds against the L1210 leukemia in mice, mutagenicity of platinum compounds in the Ames test, and conclusions and final remarks.); Appendices--(New mixed-valence chain compounds of platinum; crystal and molecular structure of tetrakis(N-methylimidazole) platinum(II)hexachloroplatinate(IV), glossary, and list of frequently used abbreviations, symbols and units.)