Preparation of DHAQ-loaded PLA-PLL-RGD Nanoparticles and Comparison of Antitumor Efficacy to Hepatoma and Breast Carcinoma

摘要

This study researches the synthesis of Arginine-Glycine-Asparti (RGD) peptide modification of copolymer: poly (lactic acid-co-L-lysine) (PLA-PLL-RGD) and the preparation of mitoxantrone (DHAQ)-loaded PLA-PLL-RGD nanoparticles (DHAQ-NP), and evaluates antitumor efficacy of exercise and DHAQ-NP in hepatoma and breast carcinoma. The experimental findings demonstrate that DHAQ-NP group have more significant antitumor efficacy than DHAQ group in hepatoma-bearing mice and breast carcinoma-bearing mice. Compared with DHAQ-NP group, the antitumor efficacy of Exercise+DHAQ-NP group are significantly lower in breast carcinoma-bearing mice. However, the antitumor efficacy of Exercise+DHAQ-NP group have no significant change in hepatoma bearing mice. This suggests that the same exercise intensity can cause different antitumor efficacies for different tumors undergoing targeted therapies.