Synthesis of 1-131 labelled 4-iodophenylacetic acid

摘要

Phenylacetate has been reported to have a potent anti-proliferative and anti-differentiating effect in haematological malignancies and in solid tumours at non-toxic concentrations. This study is a preliminary investigation into the potential of 4-iodophenylacetic acid radiolabelled by ~(131)I as a radiopharmaceutical equivalent. The radiolabelling by isotope exchange gave a radiochemical yield of 53+-6%, and a radiochemical purity of 97.8 + 1.2% as qualified by HPLC. The product contained 4% ester by-product and is suitable for studies in animals.