Juxtamedullary preglomerular vascular injury precedes glomerular and tubulointerstitial injuries during the development of hypertension

摘要

Chronic kidney disease (CKD) is a major public health problem and a risk factor for all-cause mortality and cardiovascular disease [1]. Although the mechanisms underlying the occurrence of CKD are extremely complex, hypertension is the most important independent risk factor for CKD [2]. Therefore, blood pressure control is necessary for kidney protection in hypertensive patients with CKD [3].