Lactobacillus plantarum LG42 isolated from gajami sik-hae decreases body and fat pad weights in diet-induced obese mice.

摘要

Aims: This study investigated the antiobesity effect of lactic acid bacteria (Lactobacillus plantarum LG42) isolated from gajami sik-hae. Methods and Results: Male C57BL/6J mice were divided into four groups (n=10); NDC (normal diet & DW), HDC (high-fat diet & DW), LGLAB (high-fat diet & Lactobacillus plantarum LG42, 1x107 CFU per mouse), HGLAB (high-fat diet & L. plantarum LG42, 1x109 CFU per mouse). After 12 weeks, GLAB supplemented groups showed lower body weight, with a significant reduction in epididymal and back fat. Serum and hepatic triglyceride, serum insulin and leptin levels were significantly lowered in GLAB supplemented groups. The hepatic mRNA expression of PPAR alpha and CPT-I were significantly increased in GLAB groups, whereas the level of ACC, SREBP-1 and LXR alpha were significantly decreased in GLAB groups compared with HDC group. Additionally, GLAB reduces the expression of PPAR gamma in the epididymal adipose tissue resulting in inhibition of genes regulated by PPAR gamma . Conclusion: These results suggest that the Lactobacillus plantarum LG42 has antiobesity effects in high-fat-diet-induced obese mice. Significance and Impact of the Study: These results may contribute to nutraceutical and food industries in developing functional food and probiotics based therapies for the treatment and prevention of obesity.