Evaluation of automated nucleated red blood cells counting on Sysmex XE5000 and Siemens ADVIA 2120

摘要

Nucleated red blood cells (NRBCs), also known as erythro-blasts, are the precursor of peripheral red blood cells (RBCs) which can only be found in the blood of fetus and neonate under normal conditions (1). Their appearance in blood beyond these periods is mostly attributable to an increased erythroid activity, or to damage to the marrow micro-architecture; either condition being frequently encountered in patients with hemoglobinopathies, massive acute hemorrhage, myelo-proliferative neoplasms, solid cancers, congestive heart failure, infections, burns as well as in any condition characterized by a disturbed cytokines environment (2, 3). The presence of NRBC also reflects a relatively poor prognosis (4, 5), especially in critically ill (6) and surgical intensive care patients (7). The presence of fetal NRBC in the maternal blood is also suggestive of pre-eclampsia and other pregnancy complications (8).