Scandium triflate-catalysed syntheses of N-substituted pyrroles from amine and 2,5-dimethoxytetrahydrofuran

摘要

The Clauson-Kass pyrrole synthesis catalysed by scandium triflate afforded N-substituted 2- and 3-unsubstituted pyrroles with yields ranged from good to excellent. Aromatic amines, heteroaomatic amines, 4-methylbenzenesulfonamide and 2-chlorobenzamide are good substrates in this transformation.