Transformation of 4-acetoxy-3-vinylazetidin-2-ones to 3-(1-hydroxyethyl)azetidin-2-ones and 3-ethylideneazetidin-2-ones: intermediates for carbapenem antibiotics

摘要

4-Acetoxy-3-vinylazetidin-2-one and 4-formyl-3-vinylazetidin-2-one are transformed to the carbapenem intermediates 4-acetoxy-3-(1-hydroxyethyl)azetidin-2-one and 4-acetoxy-3-ethylideneazetidin-2-one respectively, and the synthesis of a 6-vinylcarbapenem is reported.