As intermediates in the preparation of carbapenem antibiotics useful in the S-carbamoyl-2 and tiokarbamoyylifenyyli-2 (R) - (3S, 4S) -3- £ 1 (R) -trialkyylisilyylioksi) ethyl -2-oxo-4-azetidinyl propionate and -tiopropionaattijohdannaiset and Methods their preparation

摘要

Compounds of formula (I): CHEM [in which: R1 is hydrogen or a hydroxy-protecting group; R2 is alkyl, alkoxy, halogen, optionally substituted phenyl or optionally substituted phenoxy; R3 is optionally substituted pyridyl, optionally substituted quinolyl or phenyl group which has a substituent of formula -CYNR5R6, where Y is oxygen or sulphur, and R5 and R6 are each alkyl, aryl or aralkyl, or R5 and R6 and the nitrogen to which they are attached together form a heterocyclic group; R4 is hydrogen or an amino-protecting group; and Z is sulphur or oxygen]; are valuable intermediates in the preparation of carbapenem compounds and retain a desirable configuration during conversion to such carbapenem compounds.