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首页> 外文期刊>Journal of Cell Science >MITOCHONDRIAL GENOME REPOSITIONING DURING THE DIFFERENTIATION OF THE AFRICAN TRYPANOSOME BETWEEN LIFE CYCLE FORMS IS MICROTUBULE MEDIATED
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MITOCHONDRIAL GENOME REPOSITIONING DURING THE DIFFERENTIATION OF THE AFRICAN TRYPANOSOME BETWEEN LIFE CYCLE FORMS IS MICROTUBULE MEDIATED

机译:生命周期形态之间非洲三角锥的分化过程中的线粒体基因组重新定位是微管介导的

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摘要

The cell cycle of the African trypanosome requires a precise orchestration of nuclear and mitochondrial genome (kinetoplast) positioning to ensure faithful segregation during division. The controls underlying these events must be subject to modulation, however, as the respective positioning of these organelles changes during the parasite's complex life cycle. We have studied mitochondrial DNA repositioning during differentiation between the trypanosome's bloodstream and procyclic form. We have found that repositioning occurs simultaneously with the DNA replication phase of the cell cycle of the differentiating parasite. Furthermore, we demonstrate, at the cell and individual microtubule level, that this organelle repositioning is achieved via microtubule-dependent processes. Our results have implications for the control of cell differentiation and division in African trypanosomes. [References: 40]
机译:非洲锥虫的细胞周期需要核和线粒体基因组(动植物体)定位的精确协调,以确保分裂过程中的忠实分离。但是,由于这些细胞器的位置在寄生虫的复杂生命周期中会发生变化,因此必须对这些事件的控制进行调节。我们研究了锥虫体的血流和前环形式之间的分化过程中线粒体DNA的重新定位。我们发现重定位与分化寄生虫的细胞周期的DNA复制阶段同时发生。此外,我们证明,在细胞和单个微管水平,这种细胞器的重新定位是通过微管依赖性过程实现的。我们的结果对非洲锥虫中细胞分化和分裂的控制具有重要意义。 [参考:40]

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