Uncoupling of neurovascular communication after transient global cerebral ischemia is caused by impaired parenchymal smooth muscle K-ir channel function

摘要

Transient global cerebral ischemia is often followed by delayed disturbances of cerebral blood flow, contributing to neuronal injury. The pathophysiological processes underlying such disturbances are incompletely understood. Here, using an established model of transient global cerebral ischemia, we identify dramatically impaired neurovascular coupling following ischemia. This impairment results from the loss of functional inward rectifier potassium (K-IR) channels in the smooth muscle of parenchymal arterioles. Therapeutic strategies aimed at protecting or restoring cerebrovascular K-IR channel function may therefore improve outcomes following ischemia.