Microcirculatory Impairment Following Focal and Global Cerebral Ischemia in the Rat

摘要

The influence of select treatments upon cerebral blood flow (CBF) following reversible cerebral ischemia was studied in the rat. Two models of ischemia were employed: one focal (air embolization) and one global (occlusion of the carotid and vertebral arteries). CBF was measured serially by hydrogen-clearance polarography and terminally by (14C)-iodoantipyrine autoradiography. Modes of therapeutic intervention included nonsteroidal anti-inflammatory drugs (indomethacin, ibuprofen, flurbiprofen), prostacyclin, antiserum against presumptive factor-VIII antigen, glass-wool filtration of the blood, and alteration of blood pressure. Contrary to previous work in the dog, these interventions tended to blunt or to eliminate the hyperemic response after reversible ischemia. Unilateral cerebral air emboli evoked a global increase in intermediary-carbohydrate metabolites. Serial air emboli caused a stepwise deterioration in CBF that could not be ascribed to stationary intravascular air but that was accelerated by lowered blood pressure. (Author)