Macromolecular-Drug Conjugates-Nalidixic Acid and Oxacillin-Dextran

摘要

Dextran conjugates with nalidixic acid and oxacillin,were prepared in two ways:(a) by the reaction of the drugs with chloroacetylated crosslinked dextran microparticles and (b) by the reaction of the drugs with crosslinked polysaccharide microparticles in the presence of a coupling agent.The in vitro behavior of these conjugates was studied and the mechanism of drug release was determined.