SYNTHESIS OF HETEROARYL-FUSED PYRAZOLES AS P38 KINASE INHIBITORS

Sarah C. Abbot; Roland J. Billedeau; Nolan J. Dewdney; klmccaleb@gmail.com

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SYNTHESIS OF HETEROARYL-FUSED PYRAZOLES AS P38 KINASE INHIBITORS

机译：杂种融合的吡唑类作为P38激酶抑制剂的合成

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The synthesis of pyrazolo-pyridine, pyrimidine, pyrazine and pyridazine heterocycles is described. In addition, we report the utilization of 2,4-difluorophenoxide as a leaving group, to facilitate formation of the desired pyrazole adducts.

机译：描述了吡唑并吡啶，嘧啶，吡嗪和哒嗪杂环的合成。另外，我们报道了利用2，4-二氟苯氧基作为离去基团，以促进所需的吡唑加合物的形成。

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《Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry 》 |2009年第11期| 共16页
作者
Sarah C. Abbot; Roland J. Billedeau; Nolan J. Dewdney; klmccaleb@gmail.com;
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正文语种 eng
中图分类化学 ;
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1. SYNTHESIS OF HETEROARYL-FUSED PYRAZOLES AS P38 KINASE INHIBITORS [J] . Sarah C. Abbot, Roland J. Billedeau, Nolan J. Dewdney, Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry . 2009 ,第11期

机译：杂种融合的吡唑类作为P38激酶抑制剂的合成
2. Structure-based design, synthesis and biological evaluation of N-pyrazole, N'-thiazole urea inhibitors of MAP kinase p38α. [J] . Matth?us Getlik, Christian Grütter, Jeffrey R Simard, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2012 ,第1期

机译：MAP激酶p38α的N-吡唑，N'-噻唑脲抑制剂的基于结构的设计，合成和生物学评估。
3. Structure-based design, synthesis and biological evaluation of N-pyrazole, N'-thiazole urea inhibitors of MAP kinase p38α. [J] . Matth?us Getlik, Christian Grütter, Jeffrey R Simard, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2012 ,第1期

机译：基于结构的设计，合成和生物学评价N-吡唑，N'-噻唑脲的MAP激酶P38α的抑制剂。
4. A Practical Synthesis of Tetrasubstituted Imidazole p38 MAP Kinase Inhibitors: A New Method for the Synthesis of a-Amidoketones [C] . Jerry A. Murry, Doug Frantz, Lisa Frey, American Chemical Society . 2004

机译：四取代的咪唑P38映射激酶抑制剂的实际合成：一种合成A-酰胺酮的新方法
5. Development of a cellular mimetic protein kinase assay and a novel methodology for determining the mode of inhibition for multisubstrate enzymes, and rational design and synthesis of protein kinase inhibitors. [D] . Choi, Sun. 1999

机译：细胞模拟蛋白激酶测定法的发展和确定多底物酶抑制模式的新方法，以及蛋白激酶抑制剂的合理设计和合成。
6. 3D-QSAR and Molecular Docking Studies on Fused Pyrazoles as p38α Mitogen-Activated Protein Kinase Inhibitors [O] . Ping Lan, Zhi-Jian Huang, Jun-Rong Sun, 2010

机译：熔融吡唑作为p38α丝裂原活化蛋白激酶抑制剂的3D-QSAR和分子对接研究
7. Synthesis, Crystal Structure, and Activity of Pyrazole-Based Inhibitors of p38 Kinase [O] . -1

机译：P38激酶的吡唑基抑制剂的合成，晶体结构和活性

SYNTHESIS OF HETEROARYL-FUSED PYRAZOLES AS P38 KINASE INHIBITORS

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