SYNTHETIC STUDIES OF LIPOSIDOMYCIN DEGRADATION PRODUCT:MODEL STUDIES OF URACIL GROUP INTRODUCTION

摘要

The model studies of uracil group introduction for liposidomycin degradation product was described.A stereocontrolled synthesis of the liposidomycin diazepanone ring system having a phenyl substituent has been achieved.In the presence of an amino group on the diazepanone ring,the introduction of a uracil group did failed.In the model study with the Ns and formyl protecting group,the N-glycosylation proceeded smoothly to obtain the uracil compound in good yield.