AN APPROACH TO CYCLIC a-AMINO ACIDS BY A NOVEL HETERO DIELS-ALDER/INTRAMOLECULAR HYDANTOIN ENOLATE ALKYLATION STRATEGY: AN APPROACH TO HALICHLORINE

摘要

An efficient, novel synthetic strategy has been developed for preparation of cyclic a-amino acid employing an intermolecular hetero Diels-Alder reaction and an intramolecular hydantoin enolate alkylation as key steps. Application of the present hetero Diels-Alder/intramolecular hydantoin alkylation methodology to synthesis of halichlorine was explored.