NEW PREPARATION OF TRIDENTATE BIS-OXAZOLINE CARBAZOLE LIGAND EFFECTIVE FOR ENANTIOSELECTIVE NOZAKI-HIYAMA REACTION

摘要

A new preparation of the tridentate bis-oxazoline carbazole ligand 1 is described.This method features direct formation of the amide,which is a precursor of the ligand 1,via the Pd-catalyzed amidation and following BF3·OEt2 mediated oxazoline formation.This method required only 2 steps from the aryl iodide to form the bis-oxazoline ligand;hence,it would be generally used for preparing other bis-oxazoline ligands.