MECHANISTIC ASPECTS OF THE MILD-CONDITION PHTHALIMIDINE SYNTHESIS WITH USE OF 1,2,3-1H-BENZOTRIAZOLE AND 2-MERCAPTOETHANOL AS DUAL SYNTHETIC AUXILIARIES

摘要

The mild-condition phthalimidine synthesis based on Mannich-type condensation reaction between o-phthalaldehyde and p-toluidine was first achieved with use of 1,2,3-1H-benzotriazole (Bt-H) and 2-mercaptoethanol (MET) as dual synthetic auxiliaries. Mechanistic aspects based on reaction condition optimization exercises are described.