A Notable Antimutagenicity of Two Nonmutagenic Novel Oxadiazoles in Salmonella Mutagenicity Assay

摘要

The mutagenic activity of two newly synthesized oxadiazoles:l,3-bis(5-benzylthio-l,3,4-oxadiazol-2-yl)benzene (Ml)and l,4-bis(5-benzylthio-l,3,4-oxadiazol-2-yl)benzene (M2)was studied in Salmonella typhimurium strains TA97,TA100,TA102 and TA1537 in the presence and absence of S9mix.The antimutagenicity of M1 and M2 against H_2O_2,sodium azide (SA)and 4-nitro-o-phenylene diamine (NPD)using the tester strains TA102,TA100 and TA97,respectively,was also investigated.The two compounds were found to be nonmutagenic using the four tester strains.However,they showed high mutagenic repression activity against hydrogen peroxide (95% and 97% for Ml and M2,respectively,at a concentration of 335 mug/plate).Moderate mutagenic repression against NPD (58% and 55% for Ml and M2,respectively,at a concentration of 167.5 mug/plate)and low mutagenic repression against SA (21% and 33% for Ml and M2 respectively,at a concentration of 335 mug/plate)was detected.The obtained results are very encouraging to test the above mentioned compounds as anticarcinogens.