Substitution behaviour of amine-bridged dinuclear Pt(II) complexes with bio-relevant nucleophiles

摘要

Complexes of the type [Pt-2(N,N,N',N'-tetrakis(2-pyridylmethyl)diamine(H2O)(2)](4+) and [Pt-2(N,N,N',N'-tetrakis(2-pyridylmethyl)diamine(Cl)(2)](2+) were used to study their reactions with a series of bio-relevant nucleophiles, viz. thiourea, L-methionine and guanosine-5'-monophosphate (5'-GMp(2-)) as a function of nucleophile concentration and temperature. The reactions with the sulfur containing nucleophiles (thiourea and L-methionine) were followed under pseudo-first-order conditions by stopped-flow and UV-Vis spectrophotometry. The reaction with 5'-GMp(2-) was carried out under second order conditions and studied by NMR spectroscopy. The results indicate that the bridged dinuclear complexes remain intact after coordination of the studied nucleophiles for an extended period of time, which differs significantly from that reported for other multinuclear platinum complexes in the literature.