Regio- and diastereoselective synthesis of (E)-3-(2-aminochromen-4-yl)-6-aryl-substituted fulvenes

摘要

A practical base-catalyzed route was developed for the regio- and diastereoselective synthesis of (E)-3-aminochromene-6-aryl-disubstituted fulvenes in high yields up to 94% starting with the Michael addition of cyclopentadiene to 2-iminochromenes in the key step.