Regio- and diastereoselective alkylation of 2- substituted 2,4-diydro-1H- 3- pyrazino[2,1-b]quinazoline-3,6-diones

摘要

Alkylation of N~2-protected (4S)-4-alkyl-2,4-dihydro-1H- pyroazino[2,1-b]quinazoline-3,6-diones was planned to af- ford compounds that contain a fragment of the fungal metabolite 5-N-acetylardeemin, which has been described s a potent reversal gent of multiple drug resistance (MDR) in tumor cell lines.