INHIBITION OF EPOXIDE HYDROLASES AND GLUTATHIONE S-TRANSFERASE BY 2-, 3- AND 4-SUBSTITUTED DERIVATIVES OF 4-PHENYLCHALCONE AND ITS EPOXIDE

摘要

Epoxides are important intermediates in the metabolic conversion of olefinic and aromatic xenobiotics to the excretable products. They appear to be metabolized by epoxide hydrolases(EC 3.3.2.3) and glutathione S-transferase (EC 2.5.1.18). Potent inhibitors will assist the understanding of the role of the epoxide metabolism in vivo and in vitro, and may be of therapeutic or agricultural significance.