Prognostic Value of the Stem Cell Markers Epcam and CD 13 3 Expression Of Gallbladder Adenocarcinoma

摘要

Background/Aims: To investigate the expressions and prognostic value of stem cell markers, EpCAM and CD133, in benign and malignant lesions of gallbladder. Methodology: Expression of EpCAM and CD133 was assessed in gallbladder adenocarcinoma (n=100), peritumoral tissues (n=46], adenoma (n=30), polyp (n=15), and chronic cholecystitis (n=35] by using im-munohistochemistry. Results: The positive rates of EpCAM and CD133 expression were significantly higher in gallbladder adenocarcinoma than that in peritumoral tissues [x2 =15.36, X2CD133=16.05; Ps<0.01), adenoma (x2 =10.92, X2CD133=11.09; Ps<0.01), pol-yP CX2EPCAM=8.88, x2CD133=10.43; P5<0.01) and chronic cholecystitism (X2EpCAM=28.58, X2CD133=25.57; Ps<0.01). In adenocarcinoma, the positive expression of EpCAMand CD 133 was significanctly associated with differentiation, tumor mass, lymph node metastasis, invasion and overall survival. Notably, the benign lesions with positive EpCAM or /and CD133 expression showed moderately or severely atypical hyperplasia in gallbladder epithelium. The high consistence was found between the expressive levels of EpCAM and CD133 in gallbladder adenocarcinoma (X2=1O.O2, P<0.01]. Uni-tivariate Kaplan-Meier analysis showed that high level of EpCAM (P=0.004) and CD133 (P=0.012) were associated with poor overall survival. Conclusions: The elevated expression of EpCAM and/or CD133 is closely related to the carcinogenesis, progression, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma.