Damnacanthal from the congolese medicinal plant Garcinia huillensis has a potent preferential cytotoxicity against human pancreatic cancer PANC-1 cells

摘要

Screening of eight Congolese medicinal plants showed that the CHCl _3 and MeOH extracts of Aframomum melegueta (PC_(50) = 47.8 μg/mL and 13.8 μg/mL, respectively) and CHCl_3 extracts of Garcinia huillensis (PC_(50) = 17.8 μg/mL) and Securidaca longepedunculata (PC_(50) = 23.4 μg/mL) had preferential cytotoxicity against human pancreatic cancer PANC-1 cells under nutrient-deprived conditions. The active constituents of the CHCl_3 extract of G. huillensis were examined and 12 known anthraquinones were identified. Among them, damnacanthal (1) caused preferential necrotic cell death of PANC-1 and PSN-1 cells under nutrient-deprived and serum-sensitive conditions (PC _(50) = 4.46 μm and 3.77 μm, respectively).