Pharmacokinetics of Subcutaneous Selenium in Adult Llamas

摘要

Selenium (Se) deficiency disease has been described in camelids, and only clinical data are available for administration of parenteral Se supplements. This study investigated the pharmacokinetic effects of subcutaneous Se injection (0.1 mg/kg) in llamas fed a diet adequate in Se. Absorption of Se was rapid, with peak whole blood Se concentration at the first sampling time. Significant differences in whole blood Se concentration before versus after injection of Se were not found beyond 2 days after injection. Parenteral Se is unlikely to have a long-term effect on whole blood Se concentration in llamas fed adequate dietary Se.