Outer membrane translocation: numerical protein secretion nomenclature in question in mycobacteria

摘要

Consistent numerical classification of protein secretion systems according to the outer membrane translocation mechanisms is crucial in diderm bacteria. The mycobacterial ESAT-6 secretion system (Ess), more generically defined as the WXG100 secretion system (Wss), is clearly dedicated to protein translocation across the cytoplasmic membrane. Though, naming this system a “T7SS” is quite premature as the existence, nature and specificity of a putative outer membrane translocon that would enable true protein secretion in mycobacteria remains completely unknown.