Supernatant protein biomarkers of red blood cell storage hemolysis as determined through an absolute quantification proteomics technology

摘要

BACKGROUNDLaboratory technologies have highlighted the progressive accumulation of the so-called storage lesion, a wide series of alterations to stored red blood cells (RBCs) that may affect the safety and effectiveness of the transfusion therapy. New improvements in the field are awaited to ameliorate this lesion, such as the introduction of washing technologies in the cell processing pipeline. Laboratory studies that have tested such technologies so far rely on observational qualitative or semiquantitative techniques.