It has long been appreciated that cannabinoid administration alters cognitive functioning, including learning and memory. These effects are thought to arise, at least in part, from alterations in synchronous activity in the cortex and hippocampus. The synaptic mechanisms underlying these effects, however, have not been clearly delineated. In recent years, the endogenous cannabinoid system has emerged as a powerful mechanism for regulating the release of neurotransmitter from presynaptic terminals (reviewed in Kano et al. 2009).
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